Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
The use of RNA-based treatments in the field of cancer immunotherapy
M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
Circular RNA translation: novel protein isoforms and clinical significance
In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …
determine its clinical significance. Cap-independent translation of circRNAs driven by an …
The role of alternative splicing in adaptation and evolution
Regulation of gene expression plays a central role in adaptive divergence and evolution.
Although the role of gene regulation in microevolutionary processes is gaining wide …
Although the role of gene regulation in microevolutionary processes is gaining wide …
SPT6 functions in transcriptional pause/release via PAF1C recruitment
Y Aoi, AP Shah, S Ganesan, SHA Soliman, BK Cho… - Molecular cell, 2022 - cell.com
It is unclear how various factors functioning in the transcriptional elongation by RNA
polymerase II (RNA Pol II) cooperatively regulate pause/release and productive elongation …
polymerase II (RNA Pol II) cooperatively regulate pause/release and productive elongation …
Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning
Abstract N6-methyladenosine (m6A) is the most abundant internal RNA modification in
eukaryotic mRNAs and influences many aspects of RNA processing. miCLIP (m6A …
eukaryotic mRNAs and influences many aspects of RNA processing. miCLIP (m6A …
Genome organization around nuclear speckles drives mRNA splicing efficiency
The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
LncRNA FLAIL affects alternative splicing and represses flowering in Arabidopsis
How the noncoding genome affects cellular functions is a key biological question. A
particular challenge is to distinguish the effects of noncoding DNA elements from long …
particular challenge is to distinguish the effects of noncoding DNA elements from long …
Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties
ZK Ngian, YY Tan, CT Choo, WQ Lin… - Proceedings of the …, 2022 - National Acad Sciences
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β plaques and
Tau tangles in brain tissues. Recent studies indicate that aberrant splicing and increased …
Tau tangles in brain tissues. Recent studies indicate that aberrant splicing and increased …
[HTML][HTML] CRISPR-Cas9 gene therapy for Duchenne muscular dystrophy
Discovery of the CRISPR-Cas (clustered regularly interspaced short palindromic repeat,
CRISPR-associated) system a decade ago has opened new possibilities in the field of …
CRISPR-associated) system a decade ago has opened new possibilities in the field of …