Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

ND Donahue, H Acar, S Wilhelm - Advanced drug delivery reviews, 2019 - Elsevier
Nanoparticle-based therapeutics and diagnostics are commonly referred to as
nanomedicine and may significantly impact the future of healthcare. However, the clinical …

Nanoplastics and human health: hazard identification and biointerface

H Lai, X Liu, M Qu - Nanomaterials, 2022 - mdpi.com
Nanoplastics are associated with several risks to the ecology and toxicity to humans.
Nanoplastics are synthetic polymers with dimensions ranging from 1 nm to 1 μm. They are …

Corona composition can affect the mechanisms cells use to internalize nanoparticles

V Francia, K Yang, S Deville, C Reker-Smit, I Nelissen… - ACS …, 2019 - ACS Publications
Nanosized objects, such as nanoparticles and other drug carriers used in nanomedicine,
once in contact with biological environments are modified by adsorption of biomolecules on …

Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake

CD Walkey, JB Olsen, H Guo, A Emili… - Journal of the …, 2012 - ACS Publications
Delivery and toxicity are critical issues facing nanomedicine research. Currently, there is
limited understanding and connection between the physicochemical properties of a …

Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency

A Lesniak, A Salvati, MJ Santos-Martinez… - Journal of the …, 2013 - ACS Publications
The interactions between nanosized particles and living systems are commonly mediated by
what adsorbs to the nanoparticle in the biological environment, its biomolecular corona …

[HTML][HTML] Engineered nanoparticles interacting with cells: size matters

L Shang, K Nienhaus, GU Nienhaus - Journal of nanobiotechnology, 2014 - Springer
With the rapid advancement of nanoscience and nanotechnology, detailed knowledge of
interactions between engineered nanomaterials and cells, tissues and organisms has …

Cellular uptake of nanoparticles as determined by particle properties, experimental conditions, and cell type

K Kettler, K Veltman, D van De Meent… - Environmental …, 2014 - Wiley Online Library
The increased application of nanoparticles (NPs) is increasing the risk of their release into
the environment. Although many toxicity studies have been conducted, the environmental …

Toxicological impact of microplastics and nanoplastics on humans: understanding the mechanistic aspect of the interaction

S Alqahtani, S Alqahtani, Q Saquib… - Frontiers in …, 2023 - frontiersin.org
Plastic is a pervasive material that has become an indispensable part of our daily lives and
is used in various commercial products. However, plastic waste has significantly impacted …

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

SR Saptarshi, A Duschl, AL Lopata - Journal of nanobiotechnology, 2013 - Springer
Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This
interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein …

Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells

A D'Souza, A Burch, KM Dave, A Sreeram… - Journal of Controlled …, 2021 - Elsevier
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular
vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer …