Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases

TY Weng, SYA Tsai, TP Su - Journal of biomedical science, 2017 - Springer
Abstract The sigma-1 receptor (Sig-1R) is a chaperone that resides mainly at the
mitochondrion-associated endoplasmic reticulum (ER) membrane (called the MAMs) and …

Neuroglobin: From structure to function in health and disease

P Ascenzi, A di Masi, L Leboffe, M Fiocchetti… - Molecular aspects of …, 2016 - Elsevier
In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Transcriptome comparative analysis of ovarian follicles reveals the key genes and signaling pathways implicated in hen egg production

X Sun, X Chen, J Zhao, C Ma, C Yan, S Liswaniso… - Bmc Genomics, 2021 - Springer
Background Ovarian follicle development plays an important role in determination of poultry
egg production. The follicles at the various developmental stages possess their own distinct …

Transcriptome analysis of ovarian follicles reveals potential pivotal genes associated with increased and decreased rates of chicken egg production

X Chen, X Sun, IM Chimbaka, N Qin, X Xu… - Frontiers in …, 2021 - frontiersin.org
Egg production is an important economic trait in the commercial poultry industry. Ovarian
follicle development plays a pivotal role in regulation of laying hen performance and …

Neuroglobin protects astroglial cells from hydrogen peroxide‐induced oxidative stress and apoptotic cell death

F Amri, I Ghouili, M Amri, A Carrier… - Journal of …, 2017 - Wiley Online Library
Oxidative stress, resulting from accumulation of reactive oxygen species, plays a critical role
in astroglial cell death occurring in diverse neuropathological conditions. Numerous studies …

Protection by neuroglobin expression in brain pathologies

E Baez, V Echeverria, R Cabezas… - Frontiers in …, 2016 - frontiersin.org
Astrocytes play an important role in physiological, metabolic, and structural functions, and
when impaired, they can be involved in various pathologies including Alzheimer, focal …

Growth factors and neuroglobin in astrocyte protection against neurodegeneration and oxidative stress

R Cabezas, E Baez-Jurado, O Hidalgo-Lanussa… - Molecular …, 2019 - Springer
Neurodegenerative diseases, such as Parkinson and Alzheimer, are among the main public
health issues in the world due to their effects on life quality and high mortality rates. Although …

[HTML][HTML] Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat

V Di Pietro, G Lazzarino, AM Amorini, B Tavazzi… - Free Radical Biology …, 2014 - Elsevier
Neuroglobin is a neuron-specific hexacoordinated globin capable of binding various
ligands, including O 2, NO, and CO, the biological function of which is still uncertain. Various …

Testosterone protects mitochondrial function and regulates neuroglobin expression in astrocytic cells exposed to glucose deprivation

N Toro-Urrego, LM Garcia-Segura… - Frontiers in aging …, 2016 - frontiersin.org
Testosterone is a hormone that has been shown to confer neuroprotection from different
insults affecting the central nervous system (CNS). Testosterone induces this protection by …

Overexpression of neuroglobin promotes energy metabolism and autophagy induction in human neuroblastoma SH-SY5Y cells

V Manganelli, I Salvatori, M Costanzo, A Capozzi… - Cells, 2021 - mdpi.com
Neuroglobin (NGB) is an O2-binding globin mainly expressed in the central and peripheral
nervous systems and cerebrospinal fluid. Previously, it was demonstrated that NGB …