Congenital muscular dystrophy (CMD) is a class of severe early-onset muscular dystrophies
affecting skeletal/cardiac muscles as well as the central nervous system (CNS). Laminin-α2 …

LAMA2-related congenital muscular dystrophy, also known as MDC1A, is caused by loss-of-
function mutations in the alpha2 chain of Laminin-211. Loss of this protein interrupts the …

Duchenne muscular dystrophy (DMD) is caused by mutations in the gene encoding
dystrophin. Prior work has shown that DMD progression can vary, depending on the genetic …

LAMA2 deficiency, resulting from a defective or absent laminin α2 subunit, is a common
cause of congenital muscular dystrophy. It is characterized by muscle weakness from …

Background It is unclear to what extent pre-clinical studies in genetically homogeneous
animal models of amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative …

The research on laminin α2 chain-deficient congenital muscular dystrophy (LAMA2-CMD)
advanced rapidly in the last few decades, largely due to availability of good mouse models …

Muscular dystrophies (MDs) are a heterogeneous group of congenital neuromuscular
disorders whose clinical signs include myalgia, skeletal muscle weakness, hypotonia, and …

Nonalcoholic fatty liver disease (NAFLD) commonly occurs in patients with type 2 diabetes
mellitus (T2DM). Osteopontin (OPN) is a multifunctional protein with pleiotropic physiological …

Galectin-3 binding protein (Gal-3BP) is a multifunctional glycoprotein involved in cell–cell
and cell–matrix interactions known to be upregulated in cancer and various viral infections …

Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy
(LAMA2-CMD), and dystrophic symptoms progress rapidly in early childhood. Currently …