Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine

X Zhan, J Li, Y Guo, O Golubnitschaja - EPMA Journal, 2021 - Springer
Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …

An insight into iTRAQ: where do we stand now?

C Evans, J Noirel, SY Ow, M Salim… - Analytical and …, 2012 - Springer
The iTRAQ (isobaric tags for relative and absolute quantification) technique is widely
employed in proteomic workflows requiring relative quantification. Here, we review the …

Tears as a source of biomarkers for ocular and systemic diseases

NT und Hohenstein-Blaul, S Funke, FH Grus - Experimental eye research, 2013 - Elsevier
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers
which are correlated with a certain disease. Tear proteins have been investigated …

Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model

P Grotegut, N Perumal, S Kuehn, A Smit… - Journal of …, 2020 - Springer
Background Previous studies noted that intravitreal injection of S100B triggered a glaucoma-
like degeneration of retina and optic nerve as well as microglia activation after 14 days. The …

Proteomic analyses of the vitreous humour

M Angi, H Kalirai, SE Coupland… - Mediators of …, 2012 - Wiley Online Library
The human vitreous humour (VH) is a transparent, highly hydrated gel, which occupies the
posterior segment of the eye between the lens and the retina. Physiological and …

Protein biomarkers in uveitis

R Bansal, A Gupta - Frontiers in Immunology, 2020 - frontiersin.org
The diseases affecting the retina or uvea (iris, ciliary body, or choroid) generate changes in
the biochemical or protein composition of ocular fluids/tissues due to disruption of blood …

Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome

AA Kliuchnikova, NI Samokhina, IY Ilina… - …, 2016 - Wiley Online Library
Twenty‐nine human aqueous humor samples from patients with eye diseases such as
cataract and glaucoma with and without pseudoexfoliation syndrome were characterized by …

A review: proteomics in retinal artery occlusion, retinal vein occlusion, diabetic retinopathy and acquired macular disorders

LJ Cehofski, B Honoré, H Vorum - International journal of molecular …, 2017 - mdpi.com
Retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR) and
age-related macular degeneration (AMD) are frequent ocular diseases with potentially sight …

A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration

G Tezel - Progress in retinal and eye research, 2013 - Elsevier
Despite improving understanding of glaucoma, key molecular players of neurodegeneration
that can be targeted for treatment of glaucoma, or molecular biomarkers that can be useful …

Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry

H Wang, L Feng, J Hu, C Xie, F Wang - Experimental eye research, 2013 - Elsevier
Proliferative diabetic retinopathy (PDR) is a serious microangiopathic complication of
diabetes mellitus and a major cause of blindness in working-age adults. Diabetes-induced …