Mass spectrometry analysis of human tear fluid biomarkers specific for ocular and systemic diseases in the context of 3P medicine
X Zhan, J Li, Y Guo, O Golubnitschaja - EPMA Journal, 2021 - Springer
Over the last two decades, a large number of non-communicable/chronic disorders reached
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …
an epidemic level on a global scale such as diabetes mellitus type 2, cardio-vascular …
An insight into iTRAQ: where do we stand now?
The iTRAQ (isobaric tags for relative and absolute quantification) technique is widely
employed in proteomic workflows requiring relative quantification. Here, we review the …
employed in proteomic workflows requiring relative quantification. Here, we review the …
Tears as a source of biomarkers for ocular and systemic diseases
NT und Hohenstein-Blaul, S Funke, FH Grus - Experimental eye research, 2013 - Elsevier
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers
which are correlated with a certain disease. Tear proteins have been investigated …
which are correlated with a certain disease. Tear proteins have been investigated …
Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model
P Grotegut, N Perumal, S Kuehn, A Smit… - Journal of …, 2020 - Springer
Background Previous studies noted that intravitreal injection of S100B triggered a glaucoma-
like degeneration of retina and optic nerve as well as microglia activation after 14 days. The …
like degeneration of retina and optic nerve as well as microglia activation after 14 days. The …
Proteomic analyses of the vitreous humour
M Angi, H Kalirai, SE Coupland… - Mediators of …, 2012 - Wiley Online Library
The human vitreous humour (VH) is a transparent, highly hydrated gel, which occupies the
posterior segment of the eye between the lens and the retina. Physiological and …
posterior segment of the eye between the lens and the retina. Physiological and …
Protein biomarkers in uveitis
R Bansal, A Gupta - Frontiers in Immunology, 2020 - frontiersin.org
The diseases affecting the retina or uvea (iris, ciliary body, or choroid) generate changes in
the biochemical or protein composition of ocular fluids/tissues due to disruption of blood …
the biochemical or protein composition of ocular fluids/tissues due to disruption of blood …
Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome
AA Kliuchnikova, NI Samokhina, IY Ilina… - …, 2016 - Wiley Online Library
Twenty‐nine human aqueous humor samples from patients with eye diseases such as
cataract and glaucoma with and without pseudoexfoliation syndrome were characterized by …
cataract and glaucoma with and without pseudoexfoliation syndrome were characterized by …
A review: proteomics in retinal artery occlusion, retinal vein occlusion, diabetic retinopathy and acquired macular disorders
LJ Cehofski, B Honoré, H Vorum - International journal of molecular …, 2017 - mdpi.com
Retinal artery occlusion (RAO), retinal vein occlusion (RVO), diabetic retinopathy (DR) and
age-related macular degeneration (AMD) are frequent ocular diseases with potentially sight …
age-related macular degeneration (AMD) are frequent ocular diseases with potentially sight …
A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration
G Tezel - Progress in retinal and eye research, 2013 - Elsevier
Despite improving understanding of glaucoma, key molecular players of neurodegeneration
that can be targeted for treatment of glaucoma, or molecular biomarkers that can be useful …
that can be targeted for treatment of glaucoma, or molecular biomarkers that can be useful …
Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry
H Wang, L Feng, J Hu, C Xie, F Wang - Experimental eye research, 2013 - Elsevier
Proliferative diabetic retinopathy (PDR) is a serious microangiopathic complication of
diabetes mellitus and a major cause of blindness in working-age adults. Diabetes-induced …
diabetes mellitus and a major cause of blindness in working-age adults. Diabetes-induced …