Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …

Cellular senescence is a complex biological process that leads to irreversible cell‐cycle
arrest. Various extrinsic and intrinsic insults are associated with the onset of cellular …

Gene expression patterns in cancer cells are strongly influenced by posttranscriptional
mechanisms. RNA‐binding proteins (RBPs) play key roles in posttranscriptional gene …

Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Intron retention (IR) is the least well‐understood alternative splicing type in animals, and its
prevalence and function in physiological and pathological processes have long been …

Introduction ELAVL1/HuR is a keystone regulator of gene expression at the
posttranscriptional level, including stress response and homeostasis maintenance. The aim …

Senescent cells exhibit a diverse spectrum of changes in their morphology, proliferative
capacity, senescence-associated secretory phenotype (SASP) production, and …

RNA modifications, including N6-methyladenosine (m6A), critically modulate protein
expression programs in a range of cellular processes. Although the transcriptomes of cells …

Gene expression patterns are effectively regulated by turnover and translation regulatory
(TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at …