Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract.
During the development of liver cancer, which is typically driven by chronic inflammation, the …

Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …

Hypoxia is a physiological cue that impacts diverse physiological processes, including
energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the …

Inactivation of the VHL tumor suppressor protein (pVHL) is a common event in clear cell
renal carcinoma, which is the most common form of kidney cancer. pVHL performs many …