[PDF][PDF] HIF signaling pathway in pheochromocytoma and other neuroendocrine tumors.
I Jochmanova, T Zelinka… - Physiological …, 2014 - pdfs.semanticscholar.org
Hypoxia-inducible factors (HIFs) are transcription factors controlling energy, iron
metabolism, erythropoiesis, and development. Dysregulation of these proteins contributes to …
metabolism, erythropoiesis, and development. Dysregulation of these proteins contributes to …
Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma
MY Koh, V Nguyen, R Lemos Jr, BG Darnay… - Cancer research, 2015 - AACR
Clear-cell renal cell cancer (CRCC) is initiated typically by loss of the tumor-suppressor
VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2. However …
VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2. However …
The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway
Background Although tumor hypoxia poses challenges against conventional cancer
treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the …
treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the …
HIF‑α/PKM2 and PI3K‑AKT pathways involved in the protection by dexmedetomidine against isoflurane or bupivacaine‑induced apoptosis in hippocampal neuronal …
F Bao, X Kang, Q Xie, J Wu - Experimental and …, 2019 - spandidos-publications.com
The present study investigated the mechanism underlying the protective effect of
dexmedetomidine (Dex) on hippocampal neuronal HT22 cell apoptosis induced by the …
dexmedetomidine (Dex) on hippocampal neuronal HT22 cell apoptosis induced by the …
Hypoxia-inducible factors not only regulate but also are myeloid-cell treatment targets
L Kling, A Schreiber, KU Eckardt… - Journal of leukocyte …, 2021 - academic.oup.com
Hypoxia describes limited oxygen availability at the cellular level. Myeloid cells are exposed
to hypoxia at various bodily sites and even contribute to hypoxia by consuming large …
to hypoxia at various bodily sites and even contribute to hypoxia by consuming large …
The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies
J Araos, JP Sleeman, BK Garvalov - Clinical & experimental metastasis, 2018 - Springer
Hypoxia is a characteristic feature of many cancer types, which ensues when the growth of a
tumour outpaces its oxygen supply. The cellular response to reduced oxygen tension is …
tumour outpaces its oxygen supply. The cellular response to reduced oxygen tension is …
Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells
NT Chee, CH Carriere, Z Miller… - Oncology …, 2022 - spandidos-publications.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat
cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates …
cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates …
[PDF][PDF] A new HIF‐1α/RANTES‐driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART 1/HAF in mice
MY Koh, M Gagea, T Sargis, R Lemos Jr… - …, 2016 - Wiley Online Library
The hypoxia‐inducible factor (HIF), HIF‐1, is a central regulator of the response to low
oxygen or inflammatory stress and plays an essential role in survival and function of immune …
oxygen or inflammatory stress and plays an essential role in survival and function of immune …
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell …
S Chintala, T Najrana, K Toth, S Cao, FA Durrani, R Pili… - BMC cancer, 2012 - Springer
Background Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the
cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene …
cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene …
The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability
JS Bett, AFM Ibrahim, AK Garg, V Kelly… - Biochemical …, 2013 - portlandpress.com
HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to
hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in …
hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in …