Hypoxia-inducible factors (HIFs) are transcription factors controlling energy, iron
metabolism, erythropoiesis, and development. Dysregulation of these proteins contributes to …

Clear-cell renal cell cancer (CRCC) is initiated typically by loss of the tumor-suppressor
VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2. However …

Background Although tumor hypoxia poses challenges against conventional cancer
treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the …

The present study investigated the mechanism underlying the protective effect of
dexmedetomidine (Dex) on hippocampal neuronal HT22 cell apoptosis induced by the …

Hypoxia describes limited oxygen availability at the cellular level. Myeloid cells are exposed
to hypoxia at various bodily sites and even contribute to hypoxia by consuming large …

Hypoxia is a characteristic feature of many cancer types, which ensues when the growth of a
tumour outpaces its oxygen supply. The cellular response to reduced oxygen tension is …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat
cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates …

The hypoxia‐inducible factor (HIF), HIF‐1, is a central regulator of the response to low
oxygen or inflammatory stress and plays an essential role in survival and function of immune …

Background Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the
cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene …

HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to
hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in …