Living Leukocyte‐Based Drug Delivery Systems

Y Chen, D Qin, J Zou, X Li, XD Guo, Y Tang… - Advanced …, 2023 - Wiley Online Library
Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

[HTML][HTML] Biomimetic platelet membrane-coated nanoparticles for targeted therapy

H Han, R Bartolo, J Li, MA Shahbazi… - European Journal of …, 2022 - Elsevier
The development of cell membrane-modified biomimetic nanoparticles has extensively
increased during the past years due to their exceptional biocompatibility, evasion from the …

Sensitive activatable nanoprobes for real‐time ratiometric magnetic resonance imaging of reactive oxygen species and ameliorating inflammation in vivo

X Li, Y Liu, X Qi, S Xiao, Z Xu, Z Yuan, Q Liu… - Advanced …, 2022 - Wiley Online Library
Imaging‐guided real‐time monitoring of the treatment process of inflammatory diseases is
important for the timely adjustment of treatment planning to lower unnecessary side effects …

Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles

S Wang, X Guo, W Xiu, Y Liu, L Ren, H Xiao, F Yang… - Science …, 2020 - science.org
Conventional thrombolytic drugs for vascular blockage such as tissue plasminogen activator
(tPA) are challenged by the low bioavailability, off-target side effects and limited penetration …

Biomimetic nanoparticles carrying a repolarization agent of tumor-associated macrophages for remodeling of the inflammatory microenvironment following …

Y Yue, F Li, Y Li, Y Wang, X Guo, Z Cheng, N Li, X Ma… - ACS …, 2021 - ACS Publications
The complete regression of residual tumors after photothermal therapy (PTT) depends on
the activation and recognition of the immune system. However, the inevitable local …

Drug targeting via platelet membrane–coated nanoparticles

S Wang, Y Duan, Q Zhang, A Komarla, H Gong… - Small …, 2020 - Wiley Online Library
Platelets exhibit distinct surface moieties responsible for modulating their adhesion to
various disease‐relevant substrates involving vascular damage, immune evasion, and …

An inhalable hybrid biomimetic nanoplatform for sequential drug release and remodeling lung immune homeostasis in acute lung injury treatment

C Liu, L Xi, Y Liu, JCW Mak, S Mao, Z Wang, Y Zheng - ACS nano, 2023 - ACS Publications
Interactions of lung macrophages and recruited neutrophils with the lung microenvironment
continuously aggravate the dysregulation of lung inflammation in the pathogenesis of acute …

Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications

N Jan, A Madni, S Khan, H Shah… - Bioengineering & …, 2023 - Wiley Online Library
Poly (lactic‐co‐glycolic acid)(PLGA) nanoparticles (NPs) are commonly used for drug
delivery because of their favored biocompatibility and suitability for sustained and controlled …

Penetrating macrophage-based nanoformulation for periodontitis treatment

N Yan, J Xu, G Liu, C Ma, L Bao, Y Cong, Z Wang… - ACS …, 2022 - ACS Publications
Periodontitis is a chronic inflammatory disease caused by the interaction of oral
microorganisms with the host immune response. Porphyromonas gingivalis (Pg) acts as a …

Rescuing ischemic stroke by biomimetic nanovesicles through accelerated thrombolysis and sequential ischemia-reperfusion protection

W Yu, N Yin, Y Yang, C Xuan, X Liu, W Liu, Z Zhang… - Acta biomaterialia, 2022 - Elsevier
Rational design of nanomedicine to accelerate thrombolysis and sequentially avoid
thrombolysis-mediated reperfusion injury is still a challenge. Here, we develop a biomimetic …