Differentiation therapies using all-trans retinoic acid (ATRA) are highly efficient at treating
acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). However …

Histone proteins are subject to a diverse range of post-translational modifications which,
along with DNA methylation, play a major role in controlling gene expression, cell division …

Valproic acid (VPA) is a small molecule that inhibits histone deacetylase activity. Here we
report that VPA increases recombinant mRNA and protein levels in transiently transfected …

Background Genes that are overexpressed in multidrug-resistant neuroblastomas relative to
drug-sensitive neuroblastomas may provide targets for modulating drug resistance. Methods …

Epigenetic modifications affect gene expression without changes in the actual DNA
sequence. Two of the most important mechanisms include DNA methylation and histone tail …

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis
presenting with peripheral cytopenias in combination with a hyperplastic bone marrow and …

Valproic acid is an inhibitor of class I histone deacetylases. Epigenetic therapies in cancer
have been focus of a keen interest and histone deacetylase inhibitors, in particular, have …

Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing.
This review highlights the promising data for their combination with a wide range of …

The epigenome of cancer cells is determined by DNA methylation and an array of post-
translational modifications of the core histones. Epigenetic abnormalities are commonly …

Epigenetic variations can play remarkable roles in different normal and abnormal situations.
Such variations have been shown to have a direct role in the pathogenesis of various …