The distinction between heterochromatin and euchromatin in the double-strand break (DSB)
damage pathway is of interest, recent reports indicate that chromatin is not created equally …

As opposed to genetics, dealing with gene expressions by direct DNA sequence
modifications, the term epigenetics applies to all the external influences that target the …

Acute myeloid leukemia (AML) is a clinically and genetically heterogenous malignancy of
myeloid progenitor cells that affects patients of all ages. Despite decades of research and …

Valproic acid (VPA), an inhibitor of histone deacetylases, inhibits the growth of leukemia
cells and induces their differentiation in vitro. In the present study, VPA in combination with …

Background Cytarabine is used in the treatment of acute myeloid leukemia (AML). Low-dose
cytarabine can be combined with valproic acid and all-trans retinoic acid (ATRA) as AML …

All-trans retinoic acid (ATRA) plays a role in tissue development, neural function,
reproduction, vision, cell growth and differentiation, tumor immunity, and apoptosis. ATRA …

Gemtuzumab ozogamicin (GO) is a calicheamicin-conjugated antibody directed against
CD33, an antigen highly expressed on acute myeloid leukemic (AML) cells. CD33-specific …

The treatment of tumor cells with HDAC inhibitors (HDACi) induces a range of effects
including apoptosis, cell cycle arrest, differentiation and senescence, modulation of immune …

There is a critical need to identify efficacious chemopreventive agents for lung cancer that
can be taken chronically with no side effects and whose mechanisms of action do not …

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal disorders of
hematopoietic progenitors manifest by cytopenias, bleeding, infection, and potential for …