As a group of disorders, autoimmunity ranks as the third most prevalent cause of morbidity
and mortality in the W estern W orld. However, the etiology of most autoimmune diseases …

Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially
isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent …

Abstract EBV-associated T/NK–cell lymphoproliferative disease (T/NK-LPD) is defined as a
systemic illness characterized by clonal proliferation of EBV-infected T or NK cells. We …

The rise of ancient genomics has revolutionised our understanding of human prehistory but
this work depends on the availability of suitable samples. Here we present a complete …

BACKGROUND: CD27 is a lymphocyte costimulatory molecule that regulates T-cell, natural
killer (NK) cell, B-cell, and plasma cell function, survival, and differentiation. On the basis of …

Approximately 12% of all cancers worldwide are associated with viral infections. To date,
eight viruses have been shown to contribute to the development of human cancers …

The natural history of cancers associated with virus exposure is intriguing, since only a
minority of human tissues infected with these viruses inevitably progress to cancer …

We have investigated the in vivo safety, efficacy, and persistence of autologous Epstein Barr
virus (EBV)–specific cytotoxic T lymphocytes (CTLs) for the treatment of solid organ …

A relationship between viral infections and the simultaneous or subsequent development of
drug rashes has been observed in a number of clinical situations. We have recently …

CD27, a tumor necrosis factor receptor family member, interacts with CD70 and influences T-
, B-and NK-cell functions. Disturbance of this axis impairs immunity and memory generation …