Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …

Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …

The ability of antigen receptors to engage self-ligands with varying affinity is crucial for
lymphocyte development. To further explore this concept, we generated transgenic mice …

On the whole, the healthy adaptive immune system is responsive to foreign antigens and
tolerant to self. However, many individual lymphocytes have, and even require, substantial …

Glycosylceramides in mammalian species are thought to be present in the form of β-
anomers. This conclusion was reinforced by the identification of only one glucosylceramide …

The development and maturation of semi-invariant natural killer T cells (i NKT cells) rely on
the recognition of self antigens presented by CD1d restriction molecules in thymus. The …

Listeria monocytogenes is an intracellular bacterium responsible for a disease characterized
by several clinical features, such as septicemia, brain infection, abortion, and perinatal …

Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy
mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern …

The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …

A prominent population of innate CD8+ T cells develops in the thymus of several gene-
deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype …