Genetics and pathogenesis of inflammatory bowel disease
B Khor, A Gardet, RJ Xavier - Nature, 2011 - nature.com
Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
PJ Brennan, M Brigl, MB Brenner - Nature Reviews Immunology, 2013 - nature.com
Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
AE Moran, KL Holzapfel, Y Xing… - Journal of Experimental …, 2011 - rupress.org
The ability of antigen receptors to engage self-ligands with varying affinity is crucial for
lymphocyte development. To further explore this concept, we generated transgenic mice …
lymphocyte development. To further explore this concept, we generated transgenic mice …
Selection of self-reactive T cells in the thymus
GL Stritesky, SC Jameson… - Annual review of …, 2012 - annualreviews.org
On the whole, the healthy adaptive immune system is responsive to foreign antigens and
tolerant to self. However, many individual lymphocytes have, and even require, substantial …
tolerant to self. However, many individual lymphocytes have, and even require, substantial …
[HTML][HTML] The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides
L Kain, B Webb, BL Anderson, S Deng, M Holt… - Immunity, 2014 - cell.com
Glycosylceramides in mammalian species are thought to be present in the form of β-
anomers. This conclusion was reinforced by the identification of only one glucosylceramide …
anomers. This conclusion was reinforced by the identification of only one glucosylceramide …
Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus
F Facciotti, GS Ramanjaneyulu, M Lepore… - Nature …, 2012 - nature.com
The development and maturation of semi-invariant natural killer T cells (i NKT cells) rely on
the recognition of self antigens presented by CD1d restriction molecules in thymus. The …
the recognition of self antigens presented by CD1d restriction molecules in thymus. The …
Cell biology and immunology of Listeria monocytogenes infections: novel insights
F Stavru, C Archambaud, P Cossart - Immunological reviews, 2011 - Wiley Online Library
Listeria monocytogenes is an intracellular bacterium responsible for a disease characterized
by several clinical features, such as septicemia, brain infection, abortion, and perinatal …
by several clinical features, such as septicemia, brain infection, abortion, and perinatal …
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1–ICAM-1 interactions
SY Thomas, ST Scanlon, KG Griewank… - Journal of Experimental …, 2011 - rupress.org
Innate-like NKT cells conspicuously accumulate within the liver microvasculature of healthy
mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern …
mice, crawling on the luminal side of endothelial cells, but their general recirculation pattern …
[HTML][HTML] Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
AK Horst, KG Kumashie, K Neumann, L Diehl… - Cellular & molecular …, 2021 - nature.com
The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …
harbors professional and unconventional antigen-presenting cells that are crucial for …
Alternative memory in the CD8 T cell lineage
A prominent population of innate CD8+ T cells develops in the thymus of several gene-
deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype …
deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype …