The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23. 3 is a negative
regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor …

Traditional theories propose that testosterone should increase dominance and other status-
seeking behaviors, but empirical support has been inconsistent. The present research tested …

Recent insights into the regulation of the androgen receptor (AR) activity led to novel
therapeutic targeting of AR function in prostate cancer patients. Docetaxel is an approved …

Increased expression of the full-length androgen receptor (AR-FL) and AR splice variants
(AR-Vs) drives the progression of castration-resistant prostate cancer (CRPC). The levels of …

Androgens are functionally required for the normal growth of the prostate gland and in
prostate tumor development and progression. Epithelial-mesenchymal-transition (EMT) is an …

The transient receptor potential channel, subfamily V, member 6 (TRPV6), is strongly
expressed in advanced prostate cancer and significantly correlates with the Gleason> 7 …

Context: The impact of serum androgen manipulation on prostate tissue hormone levels in
normal men is unknown. Studies of men with prostate cancer have suggested that prostatic …

The androgen receptor (AR) is critical for the progression of prostate cancer to a castration-
resistant (CRPC) state. AR antagonists are ineffective due to their inability to repress the …

Deregulated tyrosine kinase signaling alters cellular homeostasis to drive cancer
progression. The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also …