An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

SH Leir, S Yin, JL Kerschner, W Cosme… - Life science …, 2020 - life-science-alliance.org
Spermatozoa released from the testis are unable to fertilize an egg without a coordinated
process of maturation in the lumen of the epididymis. Relatively little is known about the …

In search of new paradigms for epididymal health and disease: innate immunity, inflammatory mediators, and steroid hormones

MCW Avellar, CM Ribeiro, MR Dias-da-Silva… - …, 2019 - Wiley Online Library
The primary job of the epididymis is to mature and protect the luminally transiting
spermatozoa. Mounting evidence is showing that innate immune components [including Toll …

[HTML][HTML] Estrogens and development of the rete testis, efferent ductules, epididymis and vas deferens

RA Hess, RM Sharpe, BT Hinton - Differentiation, 2021 - Elsevier
Estrogen has always been considered the female hormone and testosterone the male
hormone. However, estrogen's presence in the testis and deleterious effects of estrogen …

[HTML][HTML] Crucial convolution: Genetic and molecular mechanisms of coiling during epididymis formation and development in embryogenesis

J Wong, J Gasperoni, J Fuller, SVH Grommen… - Journal of …, 2022 - mdpi.com
As embryonic development proceeds, numerous organs need to coil, bend or fold in order to
establish their final shape. Generally, this occurs so as to maximise the surface area for …

Beta-defensin126 is correlated with sperm motility in fertile and infertile men

R Aram, PTK Chan, DG Cyr - Biology of Reproduction, 2020 - academic.oup.com
A crucial function of the epididymis is providing a surface glycocalyx that is important for
sperm maturation and capacitation. Defensins are antimicrobial peptides expressed in the …

Differential gene expression and hallmarks of stemness in epithelial cells of the developing rat epididymis

J Dufresne, M Gregory, L Pinel, DG Cyr - Cell and Tissue Research, 2022 - Springer
Epididymal development can be subdivided into three phases: undifferentiated, a period of
differentiation, and expansion. The objectives of this study were (1) to assess gene …

Differential gene expression profiles of human efferent ducts and proximal epididymis

C Légaré, R Sullivan - Andrology, 2020 - Wiley Online Library
Background Gene expression patterns along the epididymis are established by specific
transcription factor networks that coordinate region‐specific functions. In rodents, the …

Epididymal embryonic development harbors TLR4/NFKB signaling pathway as a morphogenetic player

LGA Ferreira, FA Nishino, SG Fernandes… - Journal of Reproductive …, 2022 - Elsevier
The Wolffian duct (WD) is an embryonic tissue that undergoes androgen-induced
morphological changes to become the epididymis. Toll-like receptor 4 (TLR4)-and nuclear …

β-Defensins: Antimicrobial Peptides at the Intersection of Immunity and Male Fertility

V Batra, A Kumaresan, R Kumar, TK Datta - Current Concepts in Bovine …, 2022 - Springer
The mammalian spermatozoon is a consequence of extensive and intricate biochemical,
physiological, and morphological cellular differentiation events which take place in the …

[PDF][PDF] Étude de la voie de signalisation Hedgehog dans l'épididyme et dans le contrôle de la fertilité masculine

L Girardet - 2022 - corpus.ulaval.ca
Résumé La voie de signalisation Hedgehog est impliquée dans de nombreux processus
nécessaires au bon développement et maintien des organes. Elle a lieu par fixation de ses …