Fibroblasts as turned agents in cancer progression

R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

Nuclear dynamics and chromatin structure: implications for pancreatic cancer

LF Flores, BR Tader, EJ Tolosa, AN Sigafoos… - Cells, 2021 - mdpi.com
Changes in nuclear shape have been extensively associated with the dynamics and
functionality of cancer cells. In most normal cells, nuclei have a regular ellipsoid shape and …

Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy

Y Guo, K Cen, Q Chen, Y Dai, Y Mai… - Frontiers in …, 2023 - frontiersin.org
Introduction Cellular senescence is a hallmark of tumors and has potential for cancer
therapy. Cellular senescence of tumor cells plays a role in tumor progression, and patient …

LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer

X Li, S Jiang, T Jiang, X Sun, Y Guan, S Fan, Y Cheng - Cancers, 2023 - mdpi.com
Simple Summary Since TNBC shows the worst prognosis and limited treatment options,
exploring novel molecular targets is urgently needed for effective treatment of TNBC. In this …

LEM domain containing 1 promotes pancreatic cancer growth and metastasis by p53 and mTORC1 signaling pathway

X Cao, N Yao, Z Zhao, Y Fu, Y Hu, P Zhu, W Shi… - …, 2022 - Taylor & Francis
Pancreatic cancer (PC) is a common type of malignancy originating from the epithelium of
the pancreatic duct, with the most lethal feature and worst prognosis. LEM domain …

LEM domain containing 1 (LEMD1) transcriptionally activated by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by …

D Li, D Wang, H Liu, X Jiang - Bioengineered, 2022 - Taylor & Francis
Colon cancer is a highly malignant tumor in the digestive system. LEM domain containing 1
(LEMD1) is supposed to be a survival marker of poor prognosis in colon cancer. We aimed …

Strategies to Investigate Migration and Metastases in Thyroid Cancer

D Chopyk, PH Dedhia - Current Opinion in Endocrine and Metabolic …, 2024 - Elsevier
Thyroid cancer is the most common endocrine malignancy and is also one of the most
rapidly increasing cancers worldwide. Although most patients have an excellent prognosis …