Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
worldwide, as it affects up to 30% of adults in Western countries. Moreover, NAFLD is also …

Janus protein tyrosine kinase (JAK) has the ability to activate signal transducer and activator
of transcription (STAT). STAT3 is a valued member of the JAK/STAT signaling pathway. In …

The acronym nonalcoholic fatty-liver disease (NAFLD) groups a heterogeneous patient
population. Although in many patients the primary driver is metabolic dysfunction, a complex …

Non-alcoholic fatty liver disease (NAFLD) is by far the most prevalent form of liver disease
worldwide. It's also the leading cause of liver-related hospitalizations and deaths …

Precision medicine defines the attempt to identify the most effective approaches for specific
subsets of patients based on their genetic background, clinical features, and environmental …

Farnesoid X receptor (FXR) is a nuclear receptor for bile acids (BAs) that is widely
expressed in the intestine, liver and kidney. FXR has important regulatory impacts on a wide …

Metabolism-associated fatty liver disease (MAFLD) is a multifaceted disease that involves
complex interactions between various organs, including the gut and heart. It is defined by …

The liver has unique regeneration potential, which ensures the continuous dependence of
the human body on hepatic functions. As the composition and function of gut microbiota has …

Impaired adipose tissue function and insulin resistance remain instrumental in promoting
hepatic lipid accumulation in conditions of metabolic syndrome. In fact, enhanced lipid …