In human and murine studies, IFN-γ is a critical mediator immunity to influenza. IFN-γ
production is critical for viral clearance and the development of adaptive immune responses …

Vaccination has proved to be highly effective in reducing global mortality and eliminating
infectious diseases. Building on this success will depend on the development of new and …

ABSTRACT NK cells are important innate immune effectors during influenza virus infection.
However, the influenza virus seems able to use several tactics to counter NK cell recognition …

Influenza A virus (IAV) increases the presentation of class I human leukocyte antigen (HLA)
proteins that limit antiviral responses mediated by natural killer (NK) cells, but molecular …

IFN-γ is an enigmatic cytokine that shows direct anti-viral effects, confers upregulation of
MHC-II and other components relevant for antigen presentation, and that adjusts the …

A better understanding of innate responses induced by vaccination is critical for designing
optimal vaccines. Here, we studied the diversity and dynamics of the NK cell compartment …

Influenza viruses lead to substantial morbidity and mortality including~ 3-5 million cases of
severe illness and~ 290,000-650,000 deaths annually. One of the major hurdles regarding …

Several studies have highlighted the importance of murine natural killer (NK) cells in the
control of influenza virus infection, notably through the natural cytotoxicity receptor NKp46 …

Natural killer (NK) cells provide one of the initial barriers of cellular host defense against
pathogens, in particular intracellular pathogens. The role of these cells in foot-and-mouth …

Trivalent inactivated vaccines (TIV) against influenza are given to 350 million people every
year. Most of these are non-adjuvanted vaccines whose immunogenicity and protective …