Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of …
Y Ruan, Y Xiong, W Fang, Q Yu, Y Mai, Z Cao… - Journal of …, 2022 - Springer
Background Alzheimer's disease (AD) is the most common neurodegenerative disorder
without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an …
without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an …
Recent advances in drug delivery and targeting to the brain
Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …
Apolipoprotein E peptide-directed chimeric polymersomes mediate an ultrahigh-efficiency targeted protein therapy for glioblastoma
The inability to cross the blood–brain barrier (BBB) prevents nearly all chemotherapeutics
and biotherapeutics from the effective treatment of brain tumors, rendering few …
and biotherapeutics from the effective treatment of brain tumors, rendering few …
Targeting the blood-brain barrier for the delivery of stroke therapies
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …
Recent trends in the development of hydrogel therapeutics for the treatment of central nervous system disorders
Q Li, X Shao, X Dai, Q Guo, B Yuan, Y Liu… - NPG Asia …, 2022 - nature.com
The central nervous system (CNS) controls the acquisition and processing of peripheral
information to manage the behaviors of organisms. CNS disorders, including CNS injuries …
information to manage the behaviors of organisms. CNS disorders, including CNS injuries …
BBB pathophysiology–independent delivery of siRNA in traumatic brain injury
Small interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of
traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier …
traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier …
Nanoparticles as carriers for drug delivery of macromolecules across the blood-brain barrier
Introduction: Current therapies of neurodegenerative or neurometabolic diseases are, to a
large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This …
large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This …
Targeting nucleic acid-based therapeutics to tumors: Challenges and strategies for polyplexes
The current medical reality of cancer gene therapy is reflected by more than ten approved
products on the global market, including oncolytic and other viral vectors and CAR T-cells as …
products on the global market, including oncolytic and other viral vectors and CAR T-cells as …
BBPpred: sequence-based prediction of blood-brain barrier peptides with feature representation learning and logistic regression
R Dai, W Zhang, W Tang, E Wynendaele… - Journal of Chemical …, 2021 - ACS Publications
Blood-brain barrier peptides (BBPs) have a large range of biomedical applications since
they can cross the blood-brain barrier based on different mechanisms. As experimental …
they can cross the blood-brain barrier based on different mechanisms. As experimental …
Rational design of functional peptide–gold hybrid nanomaterials for molecular interactions
Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing‐related
development due to outstanding optical properties. Peptides, as newly realized functional …
development due to outstanding optical properties. Peptides, as newly realized functional …