Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing …
X Lu, Y Zhang, L Wang, G Li, J Gao, Y Wang - Drug Delivery, 2021 - Taylor & Francis
The development of suitable drug delivery carriers is significant in biomedical applications to
improve the therapeutic efficiency. Recent progress in nanotechnological fields, paved the …
improve the therapeutic efficiency. Recent progress in nanotechnological fields, paved the …
Role of nanomedicine-based therapeutics in the treatment of CNS disorders
Central nervous system disorders, especially neurodegenerative diseases, are a public
health priority and demand a strong scientific response. Various therapy procedures have …
health priority and demand a strong scientific response. Various therapy procedures have …
Biological membrane-penetrating peptides: computational prediction and applications
ECL de Oliveira, KS da Costa, PS Taube… - Frontiers in Cellular …, 2022 - frontiersin.org
Peptides comprise a versatile class of biomolecules that present a unique chemical space
with diverse physicochemical and structural properties. Some classes of peptides are able to …
with diverse physicochemical and structural properties. Some classes of peptides are able to …
B3pred: A random-forest-based method for predicting and designing blood–brain barrier penetrating peptides
The blood–brain barrier is a major obstacle in treating brain-related disorders, as it does not
allow the delivery of drugs into the brain. We developed a method for predicting blood–brain …
allow the delivery of drugs into the brain. We developed a method for predicting blood–brain …
Advances in targeted tracking and detection of soluble amyloid-β aggregates as a biomarker of Alzheimer's disease
Misfolding and aggregation of amyloid-β (Aβ) peptides are key hallmarks of Alzheimer's
disease (AD). With accumulating evidence suggesting that different Aβ species have varied …
disease (AD). With accumulating evidence suggesting that different Aβ species have varied …
Medulloblastoma: from molecular subgroups to molecular targeted therapies
Brain tumors are the leading cause of cancer-related death in children, and
medulloblastoma (MB) is the most common malignant pediatric brain tumor. Advances in …
medulloblastoma (MB) is the most common malignant pediatric brain tumor. Advances in …
[HTML][HTML] The use of liposomes functionalized with the NFL-TBS. 40–63 peptide as a targeting agent to cross the in vitro blood–brain barrier and target glioblastoma …
A Mellinger, LJ Lubitz, C Gazaille, G Leneweit… - International Journal of …, 2023 - Elsevier
Glioblastoma is the most common and aggressive brain tumor. Current treatments do not
allow to cure the patients. This is partly due to the blood–brain barrier (BBB), which limits the …
allow to cure the patients. This is partly due to the blood–brain barrier (BBB), which limits the …
Piezoelectric materials for ultrasound-driven dissociation of Alzheimer's β-amyloid aggregate structure
Piezoelectric materials can evoke electrochemical reactions by transferring charge carriers
to reactants upon receiving mechanical stimuli. We report a newly discovered function of …
to reactants upon receiving mechanical stimuli. We report a newly discovered function of …
Nanomedicine-based immunotherapy for central nervous system disorders
Central nervous system (CNS) disorders represent a broad spectrum of brain ailments with
short-and long-term disabilities, and nanomedicine-based approaches provide a new …
short-and long-term disabilities, and nanomedicine-based approaches provide a new …
[HTML][HTML] Peptide-decorated polymeric nanomedicines for precision cancer therapy
The advancement of tissue and cell-specific drug delivery systems is a key to precision
cancer therapy. Peptides, with easy synthesis, low immunogenicity and biological functions …
cancer therapy. Peptides, with easy synthesis, low immunogenicity and biological functions …