Following infection, T cells differentiate into a heterogeneous population of effector T cells
that can mediate pathogen clearance. A subset of these effector T cells possesses the ability …

The anti‐inflammatory master regulator IL‐10 is critical to protect the host from tissue
damage during acute phases of immune responses. This regulatory mechanism, central to T …

Mobilization of the T-cell response against cancer has the potential to achieve long-lasting
cures. However, it is not known how to harness antigen-presenting cells optimally to achieve …

Upon stimulation with their cognate antigen, naive T cells undergo proliferation and
differentiation into effector cells, followed by apoptosis or survival as precursors of long‐lived …

Highlights•IL-10 inhibits T cell activation by suppressing APC function.•IL-10 suppresses
TLR-signaling in dendritic cells and monocytes/macrophages.•IL-10 suppresses IFNγ …

Memory CD8+ T cells are critical for long-term immunity, but the genetic pathways governing
their formation remain poorly defined. This study shows that the IL-10-IL-21-STAT3 pathway …

One of the most fundamental problems in immunology is the seemingly schizophrenic ability
of the immune system to launch robust immunity against pathogens, while acquiring and …

RNA binding proteins are important regulators of T cell activation, proliferation, and cytokine
production. The zinc finger protein 36 (ZFP36) family genes (Zfp36, Zfp36l1, and Zfp36l2) …

Globally, over 500 million people are chronically infected with the hepatitis B virus (HBV) or
hepatitis C virus (HCV). These chronic infections cause liver inflammation, and may result in …

Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to
regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV …