Botulinum neurotoxins: biology, pharmacology, and toxicology

M Pirazzini, O Rossetto, R Eleopra… - Pharmacological …, 2017 - ASPET
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …

Botulinum toxin: State of the art

J Jankovic - Movement Disorders, 2017 - Wiley Online Library
Botulinun neurotoxin (BoNT) has emerged as one of the most multipurpose therapeutic
agents in modern medicine with more clinical applications than any other drug currently on …

Pathogenicity and virulence of Clostridium botulinum

AM Rawson, AW Dempster, CM Humphreys… - Virulence, 2023 - Taylor & Francis
Clostridium botulinum, a polyphyletic Gram-positive taxon of bacteria, is classified purely by
their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor …

Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update

M Pirazzini, C Montecucco, O Rossetto - Archives of Toxicology, 2022 - Springer
Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and
botulism, respectively, by delivering inside different types of neurons, metalloproteases …

The expanding therapeutic utility of botulinum neurotoxins

E Fonfria, J Maignel, S Lezmi, V Martin, A Splevins… - Toxins, 2018 - mdpi.com
Botulinum neurotoxin (BoNT) is a major therapeutic agent that is licensed in neurological
indications, such as dystonia and spasticity. The BoNT family, which is produced in nature …

Botulinum neurotoxin formulations: overcoming the confusion

S Samizadeh, K De Boulle - Clinical, cosmetic and investigational …, 2018 - Taylor & Francis
Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various
therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular …

Botulinum neurotoxins: mechanism of action

O Rossetto, M Pirazzini, F Fabris… - Botulinum Toxin …, 2021 - Springer
Botulinum neurotoxins (BoNTs) are a growing family of bacterial protein toxins that cause
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …

Central effects of botulinum neurotoxin—evidence from human studies

D Weise, CM Weise, M Naumann - Toxins, 2019 - mdpi.com
For more than three decades, Botulinum neurotoxin (BoNT) has been used to treat a variety
of clinical conditions such as spastic or dystonic disorders by inducing a temporary paralysis …

The travel diaries of tetanus and botulinum neurotoxins

S Surana, AP Tosolini, IFG Meyer, AD Fellows… - Toxicon, 2018 - Elsevier
Abstract Tetanus (TeNT) and botulinum (BoNT) neurotoxins, the causative agents of tetanus
and botulism, respectively, are the most potent toxic molecules known to mankind. This …

Botulinum neurotoxins in central nervous system: An overview from animal models to human therapy

S Luvisetto - Toxins, 2021 - mdpi.com
Botulinum neurotoxins (BoNTs) are potent inhibitors of synaptic vesicle fusion and
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …