Botulinum neurotoxins: biology, pharmacology, and toxicology
M Pirazzini, O Rossetto, R Eleopra… - Pharmacological …, 2017 - ASPET
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
Botulinum toxin: State of the art
J Jankovic - Movement Disorders, 2017 - Wiley Online Library
Botulinun neurotoxin (BoNT) has emerged as one of the most multipurpose therapeutic
agents in modern medicine with more clinical applications than any other drug currently on …
agents in modern medicine with more clinical applications than any other drug currently on …
Pathogenicity and virulence of Clostridium botulinum
AM Rawson, AW Dempster, CM Humphreys… - Virulence, 2023 - Taylor & Francis
Clostridium botulinum, a polyphyletic Gram-positive taxon of bacteria, is classified purely by
their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor …
their ability to produce botulinum neurotoxin (BoNT). BoNT is the primary virulence factor …
Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update
Tetanus and botulinum neurotoxins cause the neuroparalytic syndromes of tetanus and
botulism, respectively, by delivering inside different types of neurons, metalloproteases …
botulism, respectively, by delivering inside different types of neurons, metalloproteases …
The expanding therapeutic utility of botulinum neurotoxins
Botulinum neurotoxin (BoNT) is a major therapeutic agent that is licensed in neurological
indications, such as dystonia and spasticity. The BoNT family, which is produced in nature …
indications, such as dystonia and spasticity. The BoNT family, which is produced in nature …
Botulinum neurotoxin formulations: overcoming the confusion
S Samizadeh, K De Boulle - Clinical, cosmetic and investigational …, 2018 - Taylor & Francis
Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various
therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular …
therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular …
Botulinum neurotoxins: mechanism of action
O Rossetto, M Pirazzini, F Fabris… - Botulinum Toxin …, 2021 - Springer
Botulinum neurotoxins (BoNTs) are a growing family of bacterial protein toxins that cause
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …
Central effects of botulinum neurotoxin—evidence from human studies
D Weise, CM Weise, M Naumann - Toxins, 2019 - mdpi.com
For more than three decades, Botulinum neurotoxin (BoNT) has been used to treat a variety
of clinical conditions such as spastic or dystonic disorders by inducing a temporary paralysis …
of clinical conditions such as spastic or dystonic disorders by inducing a temporary paralysis …
The travel diaries of tetanus and botulinum neurotoxins
S Surana, AP Tosolini, IFG Meyer, AD Fellows… - Toxicon, 2018 - Elsevier
Abstract Tetanus (TeNT) and botulinum (BoNT) neurotoxins, the causative agents of tetanus
and botulism, respectively, are the most potent toxic molecules known to mankind. This …
and botulism, respectively, are the most potent toxic molecules known to mankind. This …
Botulinum neurotoxins in central nervous system: An overview from animal models to human therapy
S Luvisetto - Toxins, 2021 - mdpi.com
Botulinum neurotoxins (BoNTs) are potent inhibitors of synaptic vesicle fusion and
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …