[HTML][HTML] Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery

J Schnittert, R Bansal, G Storm, J Prakash - Advanced drug delivery reviews, 2018 - Elsevier
Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Alcohol abuse, alcoholism, and damage to the immune system—a review

RT Cook - Alcoholism: Clinical and Experimental Research, 1998 - Wiley Online Library
Chronic alcohol abuse exacts a major social and medical toll in the United States and other
Western countries. One of the least appreciated medical complications of alcohol abuse is …

Consequences of alcohol consumption on host defence

G Szabo - Alcohol and alcoholism, 1999 - academic.oup.com
This communication reviews recent literature and summarizes current views on the
immunomodulatory effects of acute and chronic alcohol consumption. Chronic and even …

[PDF][PDF] Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein‐2 production and intercellular adhesion molecule‐1 …

AP Bautista - Hepatology, 1997 - Wiley Online Library
This study tested the hypothesis that prolonged consumption of alcohol directly or indirectly,
through endotoxin influx in the circulation, stimulates the Kupffer cells to produce …

Neutrophilic infiltration in alcoholic hepatitis

AP Bautista - Alcohol, 2002 - Elsevier
Leukocyte infiltration in the liver is one of the most important features of alcoholic liver
disease. However, in alcoholic hepatitis, the role of polymorphonuclear neutrophils (PMNs) …

Role of integrins in fibrosing liver diseases

E Patsenker, F Stickel - American journal of physiology …, 2011 - journals.physiology.org
Integrins and other cell adhesion molecules regulate numerous physiological and
pathological mechanisms by mediating the interaction between cells and their extracellular …

Laboratory models available to study alcohol‐induced organ damage and immune variations: choosing the appropriate model

NB D'Souza El‐Guindy, EJ Kovacs… - Alcoholism: clinical …, 2010 - Wiley Online Library
The morbidity and mortality resulting from alcohol‐related diseases globally impose a
substantive cost to society. To minimize the financial burden on society and improve the …

Innate immunity and alcohol

S Kany, A Janicova, B Relja - Journal of Clinical Medicine, 2019 - mdpi.com
The innate immunity has evolved during millions of years, and thus, equivalent or
comparable components are found in most vertebrates, invertebrates, and even plants. It …

Ethanol‐induced liver injury: potential roles for egr‐1

MT Pritchard, LE Nagy - Alcoholism: Clinical and Experimental …, 2005 - Wiley Online Library
Chronic ethanol‐induced liver injury follows a typical progression from its earliest stage of
steatosis to more advanced injury, characterized by the development of inflammation …

Alcohol binge before trauma/hemorrhage impairs integrity of host defense mechanisms during recovery

P Greiffenstein, KW Mathis, CV Stouwe… - Alcoholism: Clinical …, 2007 - Wiley Online Library
Background: Alcohol abuse, both chronic and acute, is a known modulator of immune
function and is associated with increased incidence of traumatic injury. Previously, we …