The incidence of traumatic injury, frequently associated with hemorrhagic shock, is higher in
the alcohol-intoxicated individual. The outcome, as it pertains to both morbidity and mortality …

This study tests two hypotheses:(1) prior exposure to LPS induces cross‐tolerance for the
hepatic effects of subsequent short‐term alcohol intoxication; and (2) short‐term alcohol …

CXC chemokines are major chemoattractants for pulmonary polymorphonuclear leukocyte
(PMNL) recruitment. To study the effects of interferon (IFN)–γ on the pulmonary chemokine …

The mechanisms by which chronic ethanol (EtOH) consumption results in an immune-
compromised state have not been fully elucidated. No studies to date have ascertained …

Objectives: During alcoholic hepatitis (AH) monocytes traverse the vascular boundaries and
massively invade the liver. In principle, tissue extravasation can be limited through shedding …

With the use of a syngeneic model, we demonstrate that rat polymorphonuclear neutrophils
(PMNs) exacerbate ischemia-reperfusion injury in the isolated rat heart. However, PMNs …

Gut‐derived lipopolysaccharide (LPS) may contribute to hepatocellular necrosis in alcoholic
hepatitis through neutrophil sequestration in hepatic sinusoids. It is well known that the …

Endotoxin is postulated to be an important aggravating factor for alcoholic liver disease. We
have previously reported that rats fed ethanol are more vulnerable to endotoxin‐induced …

Intercellular adhesion molecule-1 (ICAM-1) has been implicated in the hepatic
microvascular dysfunction elicited by gut ischemia-reperfusion (I/R). Although the effects of …

This work tests the hypothesis that chronic alcohol intoxication suppresses the microbicidal
activity of Kupffer cells by modulating the expression of cell surface receptors associated …