Hypoglycemia is the result of defects/impairment in glucose homeostasis. The main
etiological causes are metabolic and/or endocrine and/or other congenital disorders …

Methods Evidence Retrieval and Rating The committee searched for existing evidence
synthesis reports, systematic reviews, and meta-analyses. The committee also evaluated …

Insulin secretion from pancreatic β-cells is tightly regulated to keep fasting blood glucose
concentrations within the normal range (3.5-5.5 mmol/L). Hyperinsulinaemic hypoglycaemia …

Hyperinsulinemic hypoglycemia (HI) and congenital polycystic kidney disease (PKD) are
rare, genetically heterogeneous disorders. The co-occurrence of these disorders (HIPKD) in …

The diagnosis and treatment of congenital hyperinsulinism (CHI) have made a remarkable
progress over the past 20 years and, currently, it is relatively rare to see patients who are left …

Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis
and treatment, it was considered necessary to formulate evidence-based clinical practice …

Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in
infancy. The mainstay of medical management for CHI is diazoxide. Diazoxide inhibits …

Bariatric surgery is the most effective therapeutic option for obese patients; however, it
carries substantial risks, including procedure-related complications, malabsorption, and …

Hyperinsulinaemic hypoglycaemia (HH) is a heterogeneous condition with dysregulated
insulin secretion which persists in the presence of low blood glucose levels. It is the most …

Abstract Background/Aims: Congenital hyperinsulinism (CHI) is a rare disease characterized
by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the …