Women at high risk of developing breast cancer are a heterogeneous group of women
including those with and without high-risk germline mutation/s. Prevention in these women …

Background Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing
both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may …

PURPOSE To develop recommendations for management of patients with breast cancer
(BC) with germline mutations in BC susceptibility genes. METHODS The American Society …

Background Recent progress in understanding the genetic basis of breast cancer and
widely publicized reports of celebrities undergoing risk‐reducing mastectomy (RRM) have …

PURPOSE To determine the sensitivity and specificity of genetic testing criteria for the
detection of germline pathogenic variants in women with breast cancer. MATERIALS AND …

OBJECTIVE: Prophylactic bilateral salpingo-oophorectomy is advised for women with BRCA
mutations, but there are adverse consequences of premature menopause. The majority of …

BRCA1/2 mutation carriers with breast cancer are at high risk of contralateral disease. Such
women often elect to have contralateral risk-reducing mastectomy (CRRM) to reduce the …

The outcome of bilateral prophylactic mastectomy with breast reconstruction (BPM-IBR) in
healthy BRCA1/2 mutation carriers can be potentially burdensome for body image and the …

BACKGROUND: Testing for mutations in the breast and ovarian cancer susceptibility genes
BRCA1 and BRCA2 (BRCA) has been commercially available since 1996. PURPOSE: This …

Background: This study aimed to provide a comprehensive analysis of factors that might
contribute to abdominal donor-site morbidity after abdominally based free flap breast …