Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many …

The voltage-gated Kv1. 3 K+ channel is a novel target for immunomodulation of autoreactive
effector memory T (TEM) cells that play a major role in the pathogenesis of autoimmune …

Calcium-activated potassium channels modulate calcium signaling cascades and
membrane potential in both excitable and non-excitable cells. In this article we will review …

Animal venoms are rich natural sources of bioactive compounds, including peptide toxins
acting on the various types of ion channels, ie K+, Na+, Cl-and Ca2+. Among K+ channel …

A superfamily of proteins often conserves a common structural scaffold but develops diverse
biochemical and biological functions during evolution. The understanding of evolutionary …

Effector memory T lymphocytes (T EM cells) that lack expression of CCR7 are major drivers
of inflammation in a number of autoimmune diseases, including multiple sclerosis and …

Proteomic analysis of the scorpion venom Scorpio maurus palmatus was performed using
reverse-phase HPLC separation followed by mass spectrometry determination. Sixty five …

HsTX1 toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally
amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 …

During the last two decades since the identification and characterization of T cell potassium
channels great advances have been made in the understanding of the role of these …