Opioid and α2‐adrenoceptor agonists are potent analgesic drugs and their analgesic effects
can synergize when co‐administered. These supra‐additive interactions are potentially …

Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic
antinociceptive synergy at the spinal level. The present experiments tested the interaction of …

Background To learn more about persistent pain after an incision, a rat model for
postoperative pain has been developed. To further evaluate this model, the authors …

Antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on
medetomidine studies - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Background Visceral pain is an important component of many clinical pain states. The
perispinal administration of drug combinations rather than a single agent may reduce side …

In this prospective study, the postoperative analgesic effects of intraoperative iv clonidine
were evaluated. Two hundred consecutive patients undergoing major abdominal surgery …

Multiple pathological mechanisms at multiple sensory sites may underlie the pain that
follows nerve injury. This provides a basis for recommending more than one agent, either …

The actions of the selective α 2-adrenoceptor agonist dexmedetomidine were examined on
the nociceptive C and innocuous Aβ fibre-evoked responses of dorsal horn neurones to …

The heritability of nociception and antinociception has been well established in the mouse.
The pharmacogenetics of morphine analgesia are fairly well characterized, but far less is …

Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic
and inflammatory pain. Unfortunately, opioid-related adverse effects such as respiratory …