Sind Opioide noch immer die wirkungsstärksten Analgetika im Armentarium eines
Therapeuten, so stellen jedoch Unsicherheiten in der Wahl des Produktes, der Dosierung …

Dexmedetomidine, an α2-adrenoceptor agonist which has a slight side effect on breathing,
is clinically used as an analgesic and sedative agent. Previous studies have shown …

The study evaluates the analgesic effects of epidural clonidine in patients undergoing
abdominal hysterectomy under combined epidural/general anaesthesia. Forty ASA 1–2 …

The formalin test, an experimental model of injury-induced central sensitisation, was used.
The antinociceptive interaction between intrathecal morphine and clonidine was evaluated …

We recently showed that spinal synergistic interactions between δ opioid receptors (δORs)
and α2A adrenergic receptors (α2AARs) require protein kinase C (PKC). To identify which …

A multiplicative antinociceptive interaction of morphine activity at supraspinal and spinal
sites has been clearly established and is thought to be responsible, in part, for the clinical …

Objectives: Acupuncture, an alternative medical therapy with a long history, is appealing
because it can activate endogenous analgesic mechanisms by minimally invasive means …

The regional distribution of FLFQPQRFamide binding sites on fresh unfixed cryostata
sections from post mortem specimens of human spinal cord and lower medulla oblongata …

G-Protein-coupled receptors mediate many of the hypnotic and analgesic actions of the
drugs employed in anesthesia. Notably, opioid agonists represent the most successful and …

Abnormal sensory hyperexcitability consequent to peripheral injury most likely involves
activation of N-methyl-d-aspartate (NMDA) receptors in the spinal cord. This activation may …