Epilepsy is a common neurological disorder characterized by recurrent seizures. These
seizures are due to abnormal excessive and synchronous neuronal activity in the brain …

Epileptic encephalopathies are characterized by recurrent clinical seizures and prominent
interictal epileptiform discharges seen during the early infantile period. Although epileptic …

The devastating developmental and epileptic encephalopathy of infantile epileptic spasms
syndrome (IESS) has numerous causes, including, but not limited to, brain injury, metabolic …

Objective Infantile spasm (IS) is a convulsive disease characterized by brief, symmetric axial
muscle contraction (neck, trunk, and/or extremities). IS is a type of seizure that was first …

Infantile spasms are the defining seizures of West syndrome, a severe form of early life
epilepsy with poorly-understood pathophysiology. We present a novel comparative analysis …

The Priorities in Pediatric Epilepsy Research workshop was held in the spirit of patient-
centered and patient-driven mandates for developing best practices in care, particularly for …

Objective To estimate health‐related quality of life (HRQoL) in patients with tuberous
sclerosis complex (TSC) and associated manifestations and to identify potential factors …

Vesicular chloride/proton exchangers of the CLC family are critically involved in the function
of the endosomal-lysosomal pathway. Their dysfunction leads to severe disorders including …

Sleep plays an intricate role in epilepsy and can affect the frequency and occurrence of
seizures. With nearly 35% of US adults failing to obtain the recommended 7 h of sleep every …

Introduction Children with infantile epileptic spasms syndrome (IESS) are likely to
experience poor outcomes. Researchers have investigated the factors related to its long …