Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

[HTML][HTML] Candida albicans—The Virulence Factors and Clinical Manifestations of Infection

J Talapko, M Juzbašić, T Matijević, E Pustijanac… - Journal of Fungi, 2021 - mdpi.com
Candida albicans is a common commensal fungus that colonizes the oropharyngeal cavity,
gastrointestinal and vaginal tract, and healthy individuals' skin. In 50% of the population, C …

[HTML][HTML] Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2

R Kumar, IG Rojas, M Edgerton - Frontiers in Immunology, 2022 - frontiersin.org
Candida albicans Sap6, a secreted aspartyl protease (Sap), contributes to fungal virulence
in oral candidiasis. Beside its protease activity, Sap6 contains RGD (RGDRGD) motif …

Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

M Valentine, P Rudolph, A Dietschmann, A Tsavou… - Mbio, 2024 - Am Soc Microbiol
Candida albicans can cause mucosal infections in humans. This includes oropharyngeal
candidiasis, which is commonly observed in human immunodeficiency virus infected …

[HTML][HTML] Divergent EGFR/MAPK-Mediated Immune Responses to Clinical Candida Pathogens in Vulvovaginal Candidiasis

J Zhang, J Peng, D Li, H Mei, Y Yu, X Li, X She… - Frontiers in …, 2022 - frontiersin.org
Vulvovaginal candidiasis (VVC) is characterized by symptomatic inflammatory responses in
the vagina caused by Candida albicans and non-albicans Candida (NAC) species. The …

[HTML][HTML] Alterations in the Level of Ergosterol in Candida albicans' Plasma Membrane Correspond with Changes in Virulence and Result in Triggering Diversed …

D Derkacz, A Krasowska - International Journal of Molecular Sciences, 2023 - mdpi.com
Opportunistic pathogen Candida albicans possesses multiple virulence factors which
enable colonization and infection of host tissues. Candida-related infections frequently occur …

[HTML][HTML] Solubility affects IL-1β-producing activity of the synthetic candidalysin peptide

T Mori, H Kataoka, G Tanabe, T Into - Plos one, 2022 - journals.plos.org
Candidalysin, a peptide toxin produced specifically from hyphae of Candida albicans, plays
a crucial role in C. albicans pathogenesis in the oral cavity and vagina. Synthetic peptides …

[HTML][HTML] LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection

Y Wang, H Xu, N Chen, J Yang, H Zhou - Pharmaceutics, 2022 - mdpi.com
Despite various drugs work against Candida, candidiasis represents clinical management
challenges worldwide due to the rising incidence and recurrence rate, as well as epidemics …

Microbiome: Role in Inflammatory Skin Diseases

XE Zhang, P Zheng, SZ Ye, X Ma, E Liu… - Journal of …, 2024 - Taylor & Francis
As the body's largest organ, the skin harbors a highly diverse microbiota, playing a crucial
role in resisting foreign pathogens, nurturing the immune system, and metabolizing natural …

Heparin interacts with candidalysin and neutralizes its cytotoxicity to oral epithelial cells

E Domae, A Kamada, Y Yoshikawa, T Ikeo - Journal of Oral Biosciences, 2023 - Elsevier
Objectives Candidalysin is a peptide toxin produced by Candida albicans that causes
damage to epithelial cells by destabilizing the plasma membrane. This study aimed to …