Cognitive impairment in schizophrenia involves a broad array of nonsocial and social
cognitive domains. It is a core feature of the illness, and one with substantial implications for …

The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …

Background A lack of a sufficiently large sample at single sites causes poor generalizability
in automatic diagnosis classification of heterogeneous psychiatric disorders such as …

Background Current fMRI-based classification approaches mostly use functional
connectivity or spatial maps as input, instead of exploring the dynamic time courses directly …

Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent
finding in schizophrenia, and include a large effect size elevation in dopamine synthesis …

Schizophrenia is hypothesized to arise from disrupted brain connectivity. This
“dysconnectivity hypothesis” has generated interest in discovering whether there is …

The consumption of a diet high in fat and sugar can lead to the development of obesity, type
2 diabetes mellitus (T2DM), cardiovascular disease and cognitive decline. In the human gut …