The vital role for nitric oxide in intraocular pressure homeostasis
Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research
PV Rao, PP Pattabiraman, C Kopczynski - Experimental eye research, 2017 - Elsevier
Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular
pressure (IOP) is considered to be a predominant risk factor for primary open angle …
pressure (IOP) is considered to be a predominant risk factor for primary open angle …
[HTML][HTML] Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension
Background: Y-27632 is a potent ophthalmic drug for the treatment of ocular hypertension, a
globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic …
globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic …
[HTML][HTML] Therapeutic drugs and devices for tackling ocular hypertension and glaucoma, and need for neuroprotection and cytoprotective therapies
NA Sharif - Frontiers in pharmacology, 2021 - frontiersin.org
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …
Reduction-responsive polymeric micelles for trans-corneal targeted delivery of microRNA-21-5p and glaucoma-specific gene therapy
B Han, R Zhang, L Li, C Hu, M Li, J Liu, X Sun… - Journal of Materials …, 2023 - pubs.rsc.org
The therapeutic value of microRNA (miRNA) for the treatment of glaucoma has become a
focus of attention. However, naked miRNA cannot cross the corneal barrier and reach the …
focus of attention. However, naked miRNA cannot cross the corneal barrier and reach the …
FP and EP2 prostanoid receptor agonist drugs and aqueous humor outflow devices for treating ocular hypertension and glaucoma
NA Sharif, N Odani-Kawabata, F Lu… - Experimental Eye …, 2023 - Elsevier
Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …
actions of PGs in the body. From an ocular perspective, the discovery, development, and …
[HTML][HTML] Crosstalk between MicroRNA and oxidative stress in primary open-angle glaucoma
S Tabak, S Schreiber-Avissar… - International journal of …, 2021 - mdpi.com
Reactive oxygen species (ROS) plays a key role in the pathogenesis of primary open-angle
glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular …
glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular …
[HTML][HTML] Exosome-based crosstalk in glaucoma pathogenesis: a focus on oxidative stress and neuroinflammation
L Wang, X Wei - Frontiers in Immunology, 2023 - frontiersin.org
Exosomes are membrane-bound tiny particles that are released by all live cells that contain
multiple signal molecules and extensively participate in numerous normal physical activities …
multiple signal molecules and extensively participate in numerous normal physical activities …
[HTML][HTML] MiR-29a reduces TIMP-1 production by dermal fibroblasts via targeting TGF-β activated kinase 1 binding protein 1, implications for systemic sclerosis
M Ciechomska, S O'Reilly, M Suwara… - PloS one, 2014 - journals.plos.org
Background Systemic sclerosis (SSc) is an autoimmune connective tissue disease
characterised by skin and internal organs fibrosis due to accumulation of extra cellular …
characterised by skin and internal organs fibrosis due to accumulation of extra cellular …
[HTML][HTML] Identification of candidate miRNA biomarkers for glaucoma
AG Hindle, R Thoonen, JV Jasien… - … & visual science, 2019 - iovs.arvojournals.org
Purpose: Glaucoma, a leading cause of blindness worldwide, often remains undetected until
irreversible vision loss has occurred. Treatments focus on lowering intraocular pressure …
irreversible vision loss has occurred. Treatments focus on lowering intraocular pressure …