OBJECTIVES: Detection and removal of adenomas and clinically significant serrated polyps
(CSSPs) is critical to the effectiveness of colonoscopy in preventing colorectal cancer …

Colorectal cancer (CRC) is a common malignancy and the fourth leading cause of cancer
deaths worldwide. It results from the accumulation of multiple genetic and epigenetic …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

BACKGROUND: Sessile serrated adenomas/polyps (SSAs/Ps) are premalignant lesions
susceptible to being easily overlooked by endoscopists. A detailed description of the …

Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

Background The prevalence of sessile serrated adenomas and/or polyps (SSA/Ps) is
uncertain. Objective To determine the prevalence of SSA/Ps and SSA/Ps with cytologic …

Background & Aims Genetic and epigenetic alterations contribute to the pathogenesis of
colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal …

Objective Although serrated polyps may be precursors of colorectal cancer (CRC),
prospective data on the long-term CRC risk in individuals with serrated polyps are lacking …

Molecular pathology diagnostics to subclassify diseases based on pathogenesis are
increasingly common in clinical translational medicine. Molecular pathological epidemiology …

Mutations in Adenomatous polyposis coli (APC) underlie familial adenomatous polyposis
(FAP), an inherited cancer syndrome characterized by the widespread development of …