Abstract DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial
tumor predisposition disorder with a heterozygous DICER1 germline mutation. The most …

Background Compared with adult cancers, pediatric cancers are uniquely characterized by
a genomically stable landscape and lower tumor mutational burden. Alternative splicing …

Background Neuroblastoma is an embryonal cancer of the developing sympathetic nervous
system. The genetic contribution of rare pathogenic or likely pathogenic germline variants in …

Background Neuroblastoma (NB) is the most common solid extracranial paediatric tumour.
Genome-wide association studies have driven the discovery of common risk variants, but no …

Background Nasopharyngeal carcinoma (NPC) is closely associated with genetic factors
and Epstein-Barr virus infection, showing strong familial aggregation. Individuals with a …

Significant progress has been made in the management of Wilms tumor (WT) in recent
years, mostly as a result of collaborative efforts and the implementation of protocol-driven …

Abstract Background/Purpose Cancer predisposition syndromes (CPS) are a
heterogeneous group of inherited disorders that greatly increase the risk of developing …

Over the past few years, the field of pediatric cancer has experienced a shift in momentum,
and this has led to new and exciting findings that have relevance beyond pediatric …

Background FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and
acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in …

Sarcomas are cancers of mesenchymal origin with the potential to arise in diverse anatomic
locations. With over 80 subtypes, which often demonstrate overlapping morphologies …