The immunologic specificity of the antigen receptors of T cells and B cells is the result of
random shuffling of the many genes that form the DNA code for the antigen-binding site of …

Apolipoprotein AI (apo AI) an indispensable component and a major structural protein of
high-density lipoprotein (HDL), plays a vital role in reverse cholesterol transport and cellular …

Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), essential components in the
pathogenesis of immunoinflammatory diseases, are strongly induced in monocytes by direct …

Targeted delivery of therapeutics possesses the potential to localize therapeutic agents to a
specific tissue as a mechanism to enhance treatment efficacy and abrogate side effects …

NOD. H-2h4 mice, which express I-Akon the NOD genetic background, spontaneously
develop autoimmune thyroiditis (SAT) and anti-mouse thyroglobulin (MTg) autoantibodies …

Genetic associations between rheumatoid arthritis and specific HLA class II genes provide
clues to understanding the molecular basis for disease susceptibility. There is a remarkable …

Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys
(Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis …

Gene therapy offers advantages for the immunotherapeutic delivery of cytokines or their
inhibitors. After gene transfer, these mediators are produced at relatively constant, non‐toxic …

CD4+ T cells are key mediators in the initiation and perpetuation of pathogenic immune
responses directed against self antigens, ie immune responses causing autoimmune …

The antigens that trigger the pathogenic immune response in rheumatoid arthritis (RA)
remain unknown. Until recently it was assumed that either viral or microbial antigens, or joint …