Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Uromodulin is the most abundant protein in human urine, and it forms filaments that
antagonize the adhesion of uropathogens; however, the filament structure and mechanism …

Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …

TJs maintain the epithelial barrier by regulating paracellular permeability. Since TJs are
under dynamically fluctuating intercellular tension, cells must continuously survey and repair …

Membrane expansion integrates multiple forces to mediate precise tube growth and network
formation. Defects lead to deformations, as found in diseases such as polycystic kidney …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Background Uromodulin, the most abundant protein excreted in normal urine, plays major
roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of …