The manipulation of animal mitochondrial genomes has long been a challenge due to the
lack of an effective transformation method. With the discovery of specific gene editing …

Mutations in amino acid sequences can provoke changes in protein function. Accurate and
unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but …

To expand the scope of genomic editing, a C-to-G transversion-based editor called CGBE
has been developed for precise single-nucleotide genomic editing. However, limited editing …

Base editors (BEs) are widely used as revolutionary genome manipulation tools for cell
evolution. To screen the targeted individuals, it is often necessary to expand the editing …

Base editors, which enable targeted locus nucleotide conversion in genomic DNA without
double‐stranded breaks, have been engineered as powerful tools for biotechnological and …

Recent advances in genome editing technologies are allowing investigators to engineer and
study cancer-associated mutations in their endogenous genetic contexts with high precision …

Base editors are genome editing tools that enable site‐specific base conversions through
the chemical modification of nucleobases in DNA. Adenine base editors (ABEs) convert A⋅ …

CRISPR–Cas, the bacterial immune systems, have transformed the field of genome editing
by providing efficient, easily programmable, and accessible tools for targeted genome …

BACKGROUND: Familial hypertrophic cardiomyopathy has severe clinical complications of
heart failure, arrhythmia, and sudden cardiac death. Heterozygous single nucleotide …

The current‐generation adenine base editor (ABE) ABE8e, which has evolved from the
prokaryotic evolution system, exhibits high efficiency in mediating A‐to‐G conversion and is …