CRISPR–Cas, the bacterial immune systems, have transformed the field of genome editing
by providing efficient, easily programmable, and accessible tools for targeted genome …

BACKGROUND: Familial hypertrophic cardiomyopathy has severe clinical complications of
heart failure, arrhythmia, and sudden cardiac death. Heterozygous single nucleotide …

The current‐generation adenine base editor (ABE) ABE8e, which has evolved from the
prokaryotic evolution system, exhibits high efficiency in mediating A‐to‐G conversion and is …

Adenine base editors, enabling targeted A-to-G conversion in genomic DNA, have
enormous potential in therapeutic applications. However, the currently used adenine base …

Lowe syndrome, a rare X-linked multisystem disorder presenting with major abnormalities in
the eyes, kidneys, and central nervous system, is caused by mutations in OCRL gene …

Gene editing is a growing gene engineering technique that allows accurate editing of a
broad spectrum of gene‐regulated diseases to achieve curative treatment and also has the …

Single-nucleotide variants account for about half of known pathogenic genetic variants in
human. Genome editing strategies by reversing pathogenic point mutations with minimum …

Generating A-to-C transversions in specific targets via base editing technology has been
challenging. By fusing an evolved alkyladenine DNA glycosylase with an engineered …

The development of gene editing tools has been a significant area of research in the life
sciences for nearly 30 years. These tools have been widely utilized in disease detection and …

Cytosine base editors (CBEs) and adenine base editors (ABEs) are recently developed
CRISPR-mediated genome-editing tools that do not introduce double-strand breaks. In this …