The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

The most widespread, malignant, and deadliest type of glial tumor is glioblastoma
multiforme (GBM). Despite radiation, chemotherapy, and radical surgery, the median …

Gap junction (GJ) channels and their connexins (Cxs) are complex proteins that have
essential functions in cell communication processes in the central nervous system (CNS) …

Glial cells, consisting of astrocytes, oligodendrocyte lineage cells, and microglia, account
for> 50% of the total number of cells in the mammalian brain. They play key roles in the …

Macrophages, which are the main regulators of the tumor-associated microenvironment,
play a crucial role in the progression of various tumors. The anti-inflammatory role of β …

Astrocytes and microglia are the main cell population besides neurons in the central
nervous system (CNS). Astrocytes support the neuronal network via maintenance of …

Objective Current research indicates that weakness of glucose metabolism plays an
important role in silencing of invasiveness and growth of hypoxic tumors such as GBM …

Background The glucocorticoid receptor (GR) plays a role in inflammatory pain modulation.
However, the specific role played by interleukin 6 receptor (IL-6R) in these processes …

Dexamethasone is an approved steroid for clinical use to activate or suppress cytokines,
chemokines, inflammatory enzymes and adhesion molecules. It enters the brain, by-passing …

Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the
cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels …