Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

Macrophages are key cellular contributors to the pathogenesis of COVID-19, the disease
caused by the virus SARS-CoV-2. The SARS-CoV-2 entry receptor ACE2 is present only on …

Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality
in infants< 2 years-old. Here we describe that high-fiber diet protects mice from RSV …

Dissection of the genetic basis of Aicardi–Goutières syndrome has highlighted a
fundamental link between nucleic acid metabolism, innate immune sensors and type I …

Virus–host interactions determine an infection outcome. The Asian lineage of Zika virus
(ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after …

The appearance of new dominant variants of concern (VOC) of severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2) threatens the global response to the …

Antiviral transcriptional responses and regulated cell death are crucial components of the
host response to virus infection. However, in contrast to the signaling pathways that promote …

ABSTRACT A major component of the protective antiviral host defense is contributed by the
intracellular actions of the proteins encoded by interferon-stimulated genes (ISGs); among …

The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …