Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …

Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects
in articular cartilage can induce debilitating degenerative joint diseases such as …

The progression of osteoarthritis is associated with inflammation triggered by the enzymatic
degradation of extracellular matrix in injured cartilage. Here we show that a locally injected …

Runt-related transcription factor 1 (Runx1) plays a key role in cartilage formation, but its
function in articular cartilage formation is unclear. We generated non-inducible and …

In spite of a major public health burden with increasing prevalence, current osteoarthritis
(OA) management is largely palliative with an unmet need for effective treatment. Both …

During human evolution, the knee adapted to the biomechanical demands of bipedalism by
altering chondrocyte developmental programs. This adaptive process was likely not without …

Despite acknowledgement in the scientific community of sex-based differences in cartilage
biology, the implications for study design remain unclear, with many studies continuing to …

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or
therapeutic biological interventions are available. This is likely due to the fact that OA …

Post-traumatic osteoarthritis (PTOA) associated with joint injury triggers a degenerative cycle
of matrix destruction and inflammatory signaling, leading to pain and loss of function. Here …

Osteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the
joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial …