[HTML][HTML] Solvent paramagnetic relaxation enhancement as a versatile method for studying structure and dynamics of biomolecular systems
AJ Lenard, FAA Mulder, T Madl - Progress in Nuclear Magnetic Resonance …, 2022 - Elsevier
Solvent paramagnetic relaxation enhancement (sPRE) is a versatile nuclear magnetic
resonance (NMR)-based method that allows characterization of the structure and dynamics …
resonance (NMR)-based method that allows characterization of the structure and dynamics …
Direct measurements of biomolecular electrostatics through experiments
Biomolecular electrostatics has been a subject of computational investigations based on 3D
structures. This situation is changing because emerging experimental tools allow us to …
structures. This situation is changing because emerging experimental tools allow us to …
Dynamic autoinhibition of the HMGB1 protein via electrostatic fuzzy interactions of intrinsically disordered regions
Highly negatively charged segments containing only aspartate or glutamate residues (“D/E
repeats”) are found in many eukaryotic proteins. For example, the C-terminal 30 residues of …
repeats”) are found in many eukaryotic proteins. For example, the C-terminal 30 residues of …
Measuring local electrostatic potentials around nucleic acids by paramagnetic NMR spectroscopy
Electrostatic potentials around macromolecules in the presence of mobile charges are
difficult to assess especially for highly charged systems. Here, we report measurements of …
difficult to assess especially for highly charged systems. Here, we report measurements of …
Theory and Applications of Nitroxide-based Paramagnetic Cosolutes for Probing Intermolecular and Electrostatic Interactions on Protein Surfaces
Y Okuno, CD Schwieters, Z Yang… - Journal of the American …, 2022 - ACS Publications
Solvent paramagnetic relaxation enhancement (sPRE) arising from nitroxide-based
cosolutes has recently been used to provide an atomic view of cosolute-induced protein …
cosolutes has recently been used to provide an atomic view of cosolute-induced protein …
RNA electrostatics: how ribozymes engineer active sites to enable catalysis
Electrostatic interactions are fundamental to RNA structure and function, and intimately
influenced by solvation and the ion atmosphere. RNA enzymes, or ribozymes, are catalytic …
influenced by solvation and the ion atmosphere. RNA enzymes, or ribozymes, are catalytic …
Dynamics of Cations around DNA and Protein as Revealed by 23Na Diffusion NMR Spectroscopy
Counterions are vital for the structure and function of biomolecules. However, the behavior
of counterions remains elusive due to the difficulty in characterizing mobile ions. Here, we …
of counterions remains elusive due to the difficulty in characterizing mobile ions. Here, we …
Competitive Influence of Alkali Metals in the Ion Atmosphere on Nucleic Acid Duplex Stability
SJ Arteaga, BJ Dolenz, BM Znosko - ACS omega, 2023 - ACS Publications
The nonspecific atmosphere around nucleic acids, often termed the ion atmosphere,
encompasses a collection of weak ion–nucleic acid interactions. Although nonspecific, the …
encompasses a collection of weak ion–nucleic acid interactions. Although nonspecific, the …
Computational study of the pH-dependent ionic environment around β-lactoglobulin
L da Rocha, AM Baptista… - The Journal of Physical …, 2022 - ACS Publications
Ions are involved in multiple biological processes and may exist bound to biomolecules or
may be associated with their surface. Although the presence of ions in nucleic acids has …
may be associated with their surface. Although the presence of ions in nucleic acids has …
Phosphorylation at the disordered N-end makes HuR accumulate and dimerize in the cytoplasm
B Baños-Jaime, L Corrales-Guerrero… - Nucleic Acids …, 2024 - academic.oup.com
Human antigen R (HuR) is an RNA binding protein mainly involved in maintaining the
stability and controlling the translation of mRNAs, critical for immune response, cell survival …
stability and controlling the translation of mRNAs, critical for immune response, cell survival …