Chronic, plaque-associated inflammation of the gingiva and the periodontium are among the
most common oral diseases. Periodontitis (PD) is characterized by the inflammatory …

Publisher Summary This chapter provides evidence that indicates a potential role for
superantigens in the pathogenesis of several human diseases. The term “superantigen” was …

INEFFICIENT vascular supply and the resultant reduction in tissue oxygen tension often lead
to neovascularization in order to satisfy the needs of the tissue1. Examples include the …

The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a
human class II histocompatibility complex molecule (HLA-DR1) has been determined by X …

▪ Abstract Superantigens (SAGs) are a class of immunostimulatory and disease-causing
proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T …

Staphylococcal enterotoxins are exotoxins produced by Staphylococcus aureus that
possess emetic and superantigenic properties. Prior to this research there were six …

Superantigens are products of bacteria with dual affinity for HLA-DR and the variable region
of the beta chain of the T cell receptor, leading to the stimulation of large numbers of T cells …

Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor
(TCR) complex is involved in signal transduction. However, the function of the remaining …

The recent discovery of the mode of interaction between a group of microbial proteins known
as superantigens and the immune system has opened a wide area of investigation into the …

Background and Design: Colonization of inflammatory skin diseases withStaphylococcus
aureusis a frequent phenomenon and may cause exacerbation of the skin disease …