OBJECTIVE--To investigate the role of superantigen in rheumatoid arthritis (RA) by assaying
the serum levels of staphylococcal enterotoxin B (SEB) antibodies. METHODS--Serum IgG …

The aim of this study was to further assess the role of pooled human immunoglobulin (PHIG)
on cytokine production from PBMC stimulated with a bacterial superantigen. Human PBMC …

Previous studies have shown that the presentation of some bacterial superantigens by major
histocompatibility complex (MHC) class II molecules is strongly influenced by class II …

Staphylococcal enterotoxins are major causes of food poisoning and toxic shock syndrome.
Their ability to bind to major histocompatibility complex (MHC) class II molecules has been …

Surface plasmon resonance (SPR) biosensors are optical evanescent wave sensors, where
light in total internal reflection is used to probe properties of the solution adjacent to the …

SCID-hu mice provide an in vivo model for studying the events of normal intrathymic human
T-cell development and differentiation. We injected SCID-hu mice with staphylococcal …

Superantigens bind to antigen-presenting cells on the outside of the major histocompatibility
complex (MHC) class II molecule and to T cells via the external face of the T cell receptor …

In general, patients with psoriasis present with a mild-to-moderate degree of disease
involvement. These patients usually are not hospitalized for their skin condition, and most …

Staphylococcus aureus is a facultative, gram-positive coccus intimately involved in a myriad
of human illnesses, which include food poisoning, skin infections, life-threatening shock, and …

APCs express MHC-II molecules. Binding of enterotoxins to MHC-II generates a signal
resulting in the production of TNF-α that mediates toxic shock syndrome. However, the …