Reactive oxygen species (ROS) are critically important chemical intermediates in biological
studies, due to their multiple physiologically essential functions and their often pathologically …

The history of antiarrhythmic therapy reveals these agents to be associated with a high
incidence of toxicity. Although several agents have ocular effects, amiodarone is the most …

Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the
glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase …

Amiodarone is a commonly used anti-arrhythmic agent, withwell-recognized chronic toxicity.
Less well known is amiodarone'spotential to cause acute lung damage, which can be …

Tomato products containing lycopene are believed to be associated with decreased risk of
chronic diseases including cancer, and its effects are suggested to be due to antioxidant …

Several antioxidants have been shown to reduce lysosomal phospholipidosis, which is a
potential mechanism of amiodarone toxicity, and prevent amiodarone toxicity by antioxidant …

Amiodarone is a widely used class III antiarrhythmic agent which prolongs the action
potential and refractory period by blockage of several types of myocardial potassium …

RATIONALE Several mechanisms have been anticipated for the toxicity of amiodarone, such
as oxidative stress, lipid peroxidation, phospholipidosis, free radical generation, etc …

Amiodarone may induce lung damage by direct toxicity or indirectly through inflammation.
To clarify the mechanism of direct toxicity, we briefly exposed rabbit alveolar macrophages …

Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce
severe pulmonary adverse effects, including fibrosis. Although the pathogenesis of AM …