Highlights•TACI promotes TI antibody responses and controls autoimmunity and
lymphoproliferation.•TACI integrates signals from multiple pathways in B-cells to regulate …

The B cell activating factor (BAFF) inhibitor, belimumab, is the first biologic drug approved for
the treatment of SLE, and exhibits modest, but durable, efficacy in decreasing disease flares …

We provide a robust four‐color fluorescence‐based flow cytometry protocol that
distinguishes viable dividing plasmablasts from nondividing plasma cells and, based on …

Secretory IgMs (SIgMs) were amongst the first identified immunoglobulins. However, their
importance was not fully understood and recent advances have shown they play a key role …

B cells play a pivotal role in the pathogenesis of autoimmune disease (AD) by the production
of autoantibodies, secretion of cytokines and presentation of autoantigens. As a pro-survival …

B cells and the humoral immunity are important players in the pathogenesis of autoimmune
diseases. BAFF (also known as BLYS) and a proliferation-inducing ligand APRIL are …

Autoimmunity occurs when an adaptive immune response is directed against a self-antigen.
As such, autoimmune reactions associated with the production of autoantibodies are …

Highlights•The first APRIL-deficient patient confirmed the key role of APRIL at the level of
plasmocytes.•An anti-APRIL antagonist entered a clinical trial in IgA nephrophathy.•APRIL …

Background Obesity is associated with a chronic inflammatory state and autoimmune
diseases, but little is known about the role of B cells in this context and the changes in B cell …

Systemic Lupus Erythematosus (SLE) or Lupus is a multifactorial autoimmune disease of
multiorgan malfunctioning of extremely heterogeneous and unclear etiology that affects …