Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

The success of targeted therapies and immunotherapies has created optimism that cancers
may be curable. However, not all patients respond, drug resistance is common and many …

Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

Although T lymphocytes have long been appreciated for their role in the immunosurveillance
of cancer, it has been the realization that cancer cells may ultimately escape a response …

Simple Summary The relationship between the immune system and tumours is currently one
of the most studied topics in the field of cancer. Previously, it was thought that a tumour could …

Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …

Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …

Over the last decade, various new therapies have been developed to promote anti-tumor
immunity. Despite interesting clinical results in hematological malignancies, the …

A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …