Bacterial superantigen vaccines
RG Ulrích, MA Olson, S Bavari - US Patent 8,710,185, 2014 - Google Patents
The present invention relates to genetically attenuated Super antigen toxin vaccines altered
such that Superantigen attributes are absent, however the superantigen is effectively …
such that Superantigen attributes are absent, however the superantigen is effectively …
Molecular requirements for MHC class II α-chain engagement and allelic discrimination by the bacterial superantigen streptococcal pyrogenic exotoxin C
Superantigens (SAgs) are microbial toxins that bind to both TCR β-chain variable domains
(Vβs) and MHC class II molecules, resulting in the activation of T cells in a Vβ-specific …
(Vβs) and MHC class II molecules, resulting in the activation of T cells in a Vβ-specific …
Synergistic effect between CD40 and class II signals overcome the requirement for class II dimerization in superantigen‐induced cytokine gene expression
K Mehindate, R Al‐Daccak… - European journal of …, 1996 - Wiley Online Library
Although staphylococcal enterotoxin A (SEA), B (SEB), and toxic shock syndrome toxin 1
(TSST‐1) bind to major histocompatibility complex (MHC) class II molecules, they differ in …
(TSST‐1) bind to major histocompatibility complex (MHC) class II molecules, they differ in …
Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC‐IIα
HI Krupka, BW Segelke, RG Ulrich, S Ringhofer… - Protein …, 2002 - Wiley Online Library
Staphylococcal enterotoxins (SEs) are superantigenic protein toxins responsible for a
number of life‐threatening diseases. The X‐ray structure of a staphylococcal enterotoxin A …
number of life‐threatening diseases. The X‐ray structure of a staphylococcal enterotoxin A …
Viral vectors for use in the development of biodefense vaccines
JS Lee, AG Hadjipanayis, MD Parker - Advanced drug delivery reviews, 2005 - Elsevier
The heightened concerns about bioterrorism and the use of biowarfare agents have
prompted substantial increased efforts towards the development of vaccines against a wide …
prompted substantial increased efforts towards the development of vaccines against a wide …
Functional analysis of Mycoplasma arthritidis-derived mitogen interactions with class II molecules
C Bernatchez, R Al-Daccak, PE Mayer… - Infection and …, 1997 - Am Soc Microbiol
The ability of superantigens (SAGs) to trigger various cellular events via major
histocompatibility complex (MHC) class II molecules is largely mediated by their mode of …
histocompatibility complex (MHC) class II molecules is largely mediated by their mode of …
[HTML][HTML] Identification of a secondary zinc-binding site in staphylococcal enterotoxin C2: implications for superantigen recognition
AC Papageorgiou, MD Baker, JD McLeod… - Journal of Biological …, 2004 - ASBMB
The previously determined crystal structure of the superantigen staphylococcal enterotoxin
C2 (SEC2) showed binding of a single zinc ion located between the N-and C-terminal …
C2 (SEC2) showed binding of a single zinc ion located between the N-and C-terminal …
Molecular characterization of the putative T‐cell receptor cavity of the superantigen staphylococcal enterotoxin B
C Garcia, C Briggs, L Zhang, L Guan, JL Gabriel… - …, 1998 - Wiley Online Library
A number of investigators have utilized a variety of methods to identify the structural basis for
the interaction of superantigens with the T‐cell receptor β‐chain. The previous studies …
the interaction of superantigens with the T‐cell receptor β‐chain. The previous studies …
Superantigens in demyelinating disease
Autoreactive T cells are part of the normal lymphocyte repertoire of healthy individuals [4]. In
the immune system of healthy individuals, potent regulatory mechanisms control T and B cell …
the immune system of healthy individuals, potent regulatory mechanisms control T and B cell …