Sepsis remains the primary cause of death from infection in hospital patients, despite
improvements in antibiotics and intensive-care practices. Patients who survive severe sepsis …

Sepsis has always been considered as a big challenge for pharmaceutical companies in
terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves …

The sepsis syndrome represents an improper immune response to infection and is
associated with unacceptably high rates of mortality and morbidity. The interactions between …

Introduction Although major changes of the immune system have been described in sepsis,
it has never been studied whether these may differ in relation to the type of underlying …

The complex immune response associated with sepsis results in a high rate of morbidity and
mortality, despite substantial basic science and clinical advances. Most of the research has …

Sepsis is exceedingly burdensome for hospital intensive care unit caregivers, and its
incidence, as well as sepsis-related deaths, is increasing steadily. Sepsis is characterized …

Objective and design T helper 17 (Th17) and regulatory T (T reg) lymphocytes might play
important roles in patients with severe sepsis. The association of Th17 or T reg lymphocytes …

IFNγ produced by intraperitoneal myeloid and NK cells during cecal ligation/puncture-
induced septic shock facilitates myeloid cell activation yet blockade of IFNγ does not …

Background and objective Nosocomial infections following influenza are important causes of
death, requiring early implementation of preventive measures, but predictors for nosocomial …

The role of T cell memory in sepsis is poorly understood. Recent work has demonstrated that
mice exposed to frequent antigenic stimulation, in contrast to laboratory mice, better …